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科學家可能找到了牙齒重新長回的方法

時間:2017-08-24瀏覽:0


Rejoice, hockey players: scientists may have found a way for us to regrow our own lost teeth. Researchers from the Tokyo Medical and Dental University and the RIKEN Center for Developmental Biology have figured out how to bud several functional teeth from a single tooth root. The researchers published their results last week in Scientific Reports.

    喜聞樂見:科學家可能找到了能讓我們丟失的牙齒重新長回的方法。

    日本東京醫科牙科大學和日本理化研究所發展生物學研究中心的研究人員發現了由一個牙根培育出不同功能牙齒的方法。這些研究者們上周在科學報告上發表了他們的研究成果。


Every tooth begins as a little seed-like bundle of cells. That bundle could become anything, but because of its location in the tooth-growing zone, its cells are bombarded with signals that tell them to become a tooth. Early on in the tooth development process, this bundle is known as a bud or a germ. It’s the potential hidden in these germs that interested the scientists.

    每個牙齒都是從幾個像種子一樣的細胞束分化來的,這些細胞束可以分化成任何組織,但會受到牙齒植入區域周圍組織發出的信號沖擊影響,以接收變成什么類別的牙齒的指令。在牙齒變化過程的初期,這些細胞束只是牙胚。這些牙胚所含有的潛力引起了科學家的興趣。


The researchers implanted 889 tiny mouse tooth buds in petri dishes. At different stages in the buds’ development, the scientists wrapped a little string around each one and pulled it tight. The pulling squeezed the bud into a bottleneck shape, nearly cutting it in half. The divided buds were then left to continue growing.

    研究人員在培養皿里移植了889個小鼠的牙胚,,科學家們分別把每個發育階段不相同的牙胚分別用細絲繞起來拉緊,拉力把牙胚勒成瓶頸狀,幾乎把牙胚切割成兩半,但培養皿里被分割成兩半的牙胚還在繼續不停地生長。


Just how far along the bud was in its development affected what happened next. The researchers determined that the ideal moment to tie the string around the buds was about halfway through the buds’ 14th day of development. Buds that were reshaped at that stage were able to split into two healthy tooth buds.

    牙胚的發育時間對接下來的研究成果的影響至關重要。研究人員確信把牙胚分成兩半的最好時機是在牙胚發育周期一半的時候,也就是第十四天。被分開的牙胚在這個時期能分化重塑成兩個健康的牙胚。


    The new buds were then implanted into living tissue, where they continued growing. Within 30 days, nearly 74 percent of the implanted buds had grown into fully functional teeth—teeth that could chomp, chew, and even feel pain.

    這些被重塑的牙胚被移植到活體組織中后還在繼續生長,三十天后,近乎74%被植入的牙胚發育成可以咀嚼、咬,甚至感知疼痛的功能齊全的牙齒。


So far, the scientists have only tested their multistage process in mice, but the results are promising. Other groups are currently at work on the problem as well; another article published last week suggested that we might someday be able to regenerate our teeth the same way fish do.

    目前為止,科學家們只在老鼠身上測試過這些綜合階段的實驗,但是這個實驗還是有發展前途的,近期也有其他小組在研究這個問題。上周發布的另一篇文章指出也許有一天我們能和魚類一樣長出新的牙齒。

     

    原網址http://mentalfloss.com/article/72962/someday-we-may-be-able-regrow-lost-teeth

    翻譯:陳煜樺


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